The primary aim of A User’s Guide to the Human Genome is to provide the reader with an elementary hands-on guide for browsing and analyzing data produced by the International Human Genome Sequencing Consortium and other systematic sequencing efforts. The majority of this supplement is devoted to a series of worked examples, providing an overview of the types of data available, details on how these data can be browsed, and step-by-step instructions for using many of the most commonly-used tools for sequence-based discovery.